We showed that plasma IGF-1R displayed a value for distinguishing pancreatic cancer from chronic pancreatitis and PNET (AUC = 0.713, 95% CI: 0.564–0.862, P = 0.008; AUC = 0.711, 95% CI: 0.581–0.840, P = 0.009, respectively). This evidence concerns the gene IGF1R and pancreatic neoplasm.