Removing all adjustments made for competing risks by using the time dependent Cox regression analysis yielded the following all cancers hazards for cumulative dose: glargine 0.903 (95% CI 0.849–0.962, p = 0.002), human premixed insulin 0.925 (95% CI 0.899–0.952, p<0.001), premixed analogue insulin 0.955 (95% CI 0.931–0.979, p<0.001), and regular insulin 0.966 (95% CI 0.936–0.997, p = 0.03), with no significant impact for any other treatment option. The gene discussed is INS; the disease is cancer.