CORO1A and immune system disorder: To analyze the consequences of coronin 1 depletion in human, we evaluated an individual from a consanguineous family presenting with immunodeficiency due to a homozygous missense mutation in the coronin 1 coding region, causing a valine to methionine change at the conserved amino acid position 134 (Figure S3A) that resulted in coronin 1 deficiency [31].