Both CpG-ODN and α-GalCer-mediated hepatitis are TNF/FasL/Fas pathway-dependent, and the final effectors in these types of hepatitis are FasL-expressing NKT cells activated by the TNF produced by CD11b+ Kupffer cells/macrophages [17], [21], [23], [34]. The gene discussed is FASLG; the disease is Hepatitis.