Several miR-122 target genes, which contribute to tumour-genesis, have been identified, such as ADAM10, IGF1R, CCNG1, Bcl-ω, and ADAM17 [6]–[8], and low miR-122 levels are associated with hepatocellular carcinoma (HCC) [9], for example, miR-122 level was frequently reduced in HCC tissue compared to non-tumour tissue, low miR-122 was also correlated with poor prognosis [10], [11], and over-expression of miR-122 inhibited tumour cell growth [12]. The gene discussed is IGF1R; the disease is hepatocellular carcinoma.