Thus, coffee increases the level of adiponectin, the deficiency of which leads to hyperinsulinemia [42], increases the level of free estrogens by decreasing the level of sex hormone-binding globulin (SHBG), and increases the level of circulating free insulin-like growth factor-1 by decreasing the levels of insulin-like growth factor-binding protein [9]. The gene discussed is ADIPOQ; the disease is hyperinsulinism.