A detailed examination of the most representative pathways related to these 730 predicted target genes showed a significant overrepresentation for “HIF-1 signaling pathway (hsa04066)”, “Acute myeloid leukemia (hsa05221)”, “Colorectal cancer (hsa05210)”, “Renal cell carcinoma (hsa05211)” and “Type II diabetes mellitus (hsa04930)” (Additional file 5: Figure S1). The gene discussed is SETD2; the disease is colorectal cancer.