INS and glucose measurement: After 8 weeks of treatment with CNX-011-67 agonist, a similar increase in insulin secretion (2-fold, Figure 2B lower panel) in response to oral glucose load and improvement in glucose tolerance was observed in the n-STZ-CNX-011-67 animals compared to the untreated n-STZ animals (17225 ± 786 vs 32480 ± 1697 respectively, n = 8; P < 0.01; Figure 2B upper panel) and this improved glucose tolerance was again similar to the glucose tolerance observed in the sham control animals group (18094 ± 501).