Future studies have to clarify, whether ablative radiotherapy might be utilized for local necrosis induction and concomitant nucleotide release by the dying cancer cells in order to achieve intra-tumoral monocyte recruitment, APC differentiation, and subsequent priming of adaptive anti-tumor immune responses - not only in the context of fast proliferating, hormone receptor negative and p53 mutant breast cancer. The gene discussed is NR4A1; the disease is breast cancer.