When the concentration of transfected COX-2 antisense oligonucleotides reached 50 nmol/L, the inhibition of tumor invasion was statistically significant; at a concentration of 200 nmol/L, the inhibition rate of tumor cell invasion is 50%, and at a concentration of 800 nmol/L, the inhibition rate reached a plateau. This evidence concerns the gene PTGS2 and neoplasm.