PON1 and liver disorder: But more recently research has been focused on other clinical aspects such as protective role in vascular disease as well as its use as biomarker of diseases involving mainly three situations: (a) oxidative stress, since PON1 protects against oxidation [8]; (b) inflammation, being considered PON1 as a negative acute phase protein [9] and (c) liver diseases, because PON1 is synthesized in this organ [10].