High Lgr5 expression levels were significantly correlated with lymph node metastasis (p = 0.003), late stage (p = 0.003) and unfavorable response to chemotherapy (p = 0.013) according to RECIST 1.0 criteria (Table 2, representative slides shown in Figure 2). The gene discussed is LGR5; the disease is metastatic malignant neoplasm in the lymph nodes.