In addition to the close link between ZAG levels and obesity, very recent work performed by Stepan et al. [10], Leal et al. [11], and Tedeschi et al. [12] also demonstrates that serum ZAG levels are increased in patients with preeclampsia, hemodialysis (HD), or advanced heart failure patients compared with response controls. This evidence concerns the gene AZGP1 and Obesity.