When mp53-specific CD8+ T cells from mice vaccinated with mp53/CD40L DNA were stimulated under the same conditions, the mp53-specific CD8+ T cells incubated with mp53-iTC-1/CD40L had significantly more IFN-γ+ production compared to those incubated with mp53-iTC-1 tumor cells (p<0.01) (Fig. 2C and D). The gene discussed is CD8A; the disease is neoplasm.