In order to demonstrate that PR-mediated suppression of SDF-1 and IL-6 expression is the major mechanism that reduces PCa cell invasion and migration capacity, we have transiently knocked down PR expression and observed the migration and invasion rates of PC-3 (Fig.7A–C) and C4-2B (Fig.7B–D) cells were recovered. This evidence concerns the gene IL6 and posterior cortical atrophy.