Multiple lines of evidence based on analysis using independent platforms such as Infinium Methylation 450K Bead Arrays (ENCODE), Reduced Representation Bisulfite Sequencing (ENCODE) which characterized LNCaP and PrEC cells, along with MethylPlex NGS sequencing study that characterized LNCaP, PrEC and prostate cancer clinical specimens supported differential methylation of DSC3 gene promoter in prostate cancer. Here, DSC3 is linked to prostate carcinoma.