TNFRSF1B and neoplasm: Preferential accumulation of TNFR2+ Tregs in tumor-infiltrating lymphocytes (TILs) may have significant clinical value as inhibition of TNFR2/p75 in this subset of TILs will render them more sensitive to administration of small exogenous doses of TNF, therefore inducing apoptosis and necrosis of these cells.