First, there are inhibitors of the TNF family, such as monoclonal antibodies infliximab, adalimumab, or a circulating receptor fusion protein such as etanercept, that are predominantly used for the treatment of autoimmune diseases, i.e., rheumatoid arthritis (RA) or ankylosing spondylitis. The gene discussed is TNF; the disease is ankylosing spondylitis.