Preferential accumulation of TNFR2+ Tregs in tumor-infiltrating lymphocytes (TILs) may have significant clinical value as inhibition of TNFR2/p75 in this subset of TILs will render them more sensitive to administration of small exogenous doses of TNF, therefore inducing apoptosis and necrosis of these cells. The gene discussed is TNF; the disease is neoplasm.