In fact, the name tumor necrosis factor speaks for itself – the more tumor cells die, the more endogenous TNF will be produced locally in the tumor tissue, and in the absence of the signaling through p75 most of TNF signaling will go through p55 (pro-apoptotic receptor), hence causing more tumor and endothelial cell death (Fig. 3A–C and Fig. 4A–F). Here, TNFRSF1B is linked to neoplasm.