Moreover, only in rmTNF-injected p75KD/LLC tumors there was no statistical significant difference between tumor volumes (206 ± 26.5 mm3 vs. 291 ± 105 mm3, P  =  NS) before injections vs. end of study (Fig. 2B and C, magenta bars), strongly suggesting that blocking p75 expression in tumor tissue combined with administration of small dose of rmTNF can significantly inhibit aggressive LLC tumor growth. This evidence concerns the gene TNFRSF1B and neoplasm.