Filarial-specific immune responses increased after the onset of patent infections in WT mice and when compared to ST2-ko mice there were no differences in local (cytokine levels within the thoracic cavity lavage, after restimulation of thoracic cavity cells and frequencies of IL-4+ and IL-5+ CD4+ T-cells) and systemic (spleen cell cytokine production after restimulation and parasite-specific and total IgE levels) Type 2 immune responses. The gene discussed is IGHE; the disease is infection.