GRM5 and temporal lobe epilepsy: In human temporal lobe epilepsy (TLE), Blümcke, et al. reported up-regulated mGluR1 though mGluR5 did not show any significant change [7], however, Notenboom, et al. showed up-regulation of mGluR5 in TLE patients, particularly in hippocampal non-sclerosis groups [8].