In the hippocampus, mGluR5 BPND of epilepsy models decreased in acute (1.11±0.20) and subacute (1.20±0.18) periods compared to controls (1.63±0.18) (U = 0, p<0.01 for acute period vs. control and for subacute period vs. control). This evidence concerns the gene GRM5 and epilepsy.