Moreover, human Kv1.5 (hKv1.5) is encoded by KCNA5 and KCNA5 loss-of-function mutations have been reported to produce kindred atrial arrhythmia, which suggest that the genetic alteration of hKv1.5 may substantially enhance arrhythmia susceptibility [8], [9]. This evidence concerns the gene KCNA5 and cardiac arrhythmia.