The gene was a previously implicated in a study by Inserm-Lille2-IPL UMR744 [2], British, American, and French researchers have now shown that, on this same region of chromosome 6, mutations in the TREM2 gene are associated with a five-fold increased risk of developing late-onset Alzheimer’s disease. This evidence concerns the gene TREM2 and early-onset autosomal dominant Alzheimer disease.