AKT1 and Osteopenia: Based on our in vitro data, we envision that histomorphometric studies would demonstrate reduced osteoclast activity in Akt1-deficient mice, and when coupled with our observations on decreased proliferation of long bone osteoblast precursors from male mice lacking Akt1 (Fig. 6), support the hypothesis that the bone phenotype of Akt1 deficiency resembles ‘low-turnover’ osteopenia [3].