Two ovarian cancer cell lines that express matriptase, OCAR3 and OV2008, were also studied and revealed identical characteristics with respect to matriptase activation induced by exposure to pH 6.0 buffer with the rapid formation of activated matriptase-HAI-1 complexes, which were depleted by the mAb M69 (Fig. 5A). This evidence concerns the gene SPINT1 and ovarian carcinoma.