However, depletion of nine genes including TLL1, AGMAT, NEDD9, PRSS21, IFITM1, PLEKHG1, SLC16A6, ICAM1 and ACSL5 resulted in 1.6–2.7-fold enhancement of A92E infectivity in the absence of CsA and 1.4–2.0-fold decrease in CsA enhancement of A92E infection. This evidence concerns the gene PRSS21 and infection.