As previously reported [30], several factors were associated with reduced eVO2 max such as older age, Black or other ethnicity, female gender, high school education, former and never smoking status, overweight/obesity, lower physical activity levels, hypertension, diabetes, and elevated cholesterol, pulse, white blood cell count and CRP (Tables S2 and S3). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.