Our research group observed in Spanish menstruating women that a large percentage of the genetic variation of serum transferrin was explained by two Single Nucleotide Polymorphisms (SNPs) located in the transferrin (Tf) gene and two in the haemochromatosis (HFE) gene [15]; and that the SNP rs1375515, located in a calcium channel gene (CACNA2D3), may play important roles in iron status [16]. Here, TF is linked to hereditary hemochromatosis.