To determine the consequences of over-expression or suppression of HIF-lα in PDAC, siRNA HIF-1α interference was applied into pancreatic cancer cell line BXPC3 to inhibit HIF-lα expression, and pcDNA HIF-lα was applied into Mia -paca-2 cells to over-express HIF-lα. Here, HIF1A is linked to familial pancreatic carcinoma.