STAT3 and breast cancer: Intriguingly, it has also been reported that high nuclear expression of Tyr705-phosphorylated STAT3 is correlated with improved survival, smaller tumors, or less aggressive histology in various tumors, including breast cancer [73,74], head and neck cancer [75], lung cancer [76], gastric cancer [77], soft tissue leiomyosarcoma [78], and advanced rectal cancer [79].