It has been shown that upregulated expression of STAT3 is associated with more malignant behavior of tumor cells and worse prognosis in a variety of human malignancies, e.g., cancers of the breast, prostate, ovary, lung, head and neck, esophagus, and brain [53,54,55,56,57,58,59,60,61]. This evidence concerns the gene STAT3 and neoplasm.