Inhibition of SYK activity by a small molecule prevents ROS-induced activation of STAT3 and overcomes the resistance of human B-lineage leukemia and lymphoma cells to ROS-induced apoptosis [258], indicating that SYK plays an indispensable role in oxidative stress-induced STAT3 activation in B-cell leukemia and lymphoma cells. This evidence concerns the gene STAT3 and lymphoma.