High levels of STAT3 protein expression have been associated with poor tumor differentiation and/or development of metastasis and poor survival rates in leukemia [69], lymphoma [70], osteosarcoma [71,72], glioma [63], gastric adenocarcinoma [73,74], colorectal cancer [75,76], bladder cancer [77], and cervical squamous cell carcinoma [78] cases. Here, STAT3 is linked to central nervous system cancer.