LMP1 is essential for EBV-mediated growth transformation because of its activation of numerous oncogenic signaling pathways.16 Even though several studies reported that EBV and LMP1 might affect intercellular energy metabolism, an EBV-modulated global biochemical profile has not yet been published and the underlying mechanism has rarely been investigated.17,18 In our study, we used a large-scale metabolic profiling approach and found that EBV and LMP1 modulated metabolic changes in NPC cells and, in particular, elevated glycolysis. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.