To further probe the connection between PI3-K/Akt and c-Myc stabilization in the presence of LMP1, we used Wortmannin, a specific inhibitor of the PI3-K/Akt pathway, to treat NPC cells and examined whether or not c-Myc stabilization would be affected by the inhibition of the PI3-K/Akt signaling pathway in these cells. This evidence concerns the gene AKT1 and nasopharyngeal carcinoma.