HK2 has been demonstrated to be required for tumor initiation and maintenance, and it has been recognized as a therapeutic target in multiple cancers.27 Recently, two NPC clinical investigations reported that high 18F-FDG uptake indicates poor outcome in patients with NPC,28,29 and the high 18F-FDG uptake is highly dependent on HK2. The gene discussed is HK2; the disease is nasopharyngeal carcinoma.