Besides c-Myc, HIF-1a is another important transcriptional factor responsible for the transcription of HK2,37 and its stability can also be regulated by LMP1 in EBV-related cancers.38,39 LMP1-mediated upregulation of HIF-1a might also contribute to the transactivation of HK2. The gene discussed is PDLIM7; the disease is cancer.