However to our knowledge this is the first report in medulloblastoma to document the functional importance of mitotic kinases and in particular WEE1. WEE1 controls the G2-M transition by catalyzing the inhibitory phosphorylation of CDK1 thus preventing the Cyclin B-CDK1 complex from driving cells into mitosis [37]. Here, WEE1 is linked to medulloblastoma.