TNF and amyotrophic lateral sclerosis: Animal models of ALS also suggest a role of neuroinflammation in the events leading to motor neuron loss and disease progression including microglial dysregulation, an increased secretion of pro-inflammatory markers such as INF-γ, TNF-α, a decreased secretion of protective cytokines such as IL-4, Th1-lymphocytes infiltration and Th-2 depletion [5,19-21].