Similarly, aspirin use for 2 days at 5 days before the brain ischemia and then for 3 days starting from surgery day to induce the brain ischemia, continuation of aspirin use throughout the perioperative period, and the combination of DAPT and aspirin use throughout the perioperative period also reduced the expression of NICD, IL-6 and IL-1β in the ischemic penumbral brain tissues (Figure 7). Here, IL6 is linked to brain ischemia.