Criteria 1: ≤2 ATP3 metabolic syndrome criteria: fasting plasma glucose 5.6–6.9 mmol L−1, waist circumference > 102 cm in men or >88 cm in women, fasting triglycerides ≥ 1.7 mmol L−1, HDL-cholesterol < 1.0 mmol L−1 in men or <1.3 mmol L−1 in women, blood pressure ≥ 130/85 mmHg or current treatment for hypertensionCriteria 2: HOMA-IR ([Fasting glucose × Fasting insulin]/22.5) <75th percentileBMI ≥ 30 kg m−2. This evidence concerns the gene INS and metabolic syndrome.