Clinical outcomes were measured in 16 studies using one or several parameters: blood pressure (6), glycated hemoglobin (HbA1C) (2), psychiatric symptoms (2), low-density lipoprotein cholesterol (LDL-C) levels (1), pain reduction (1), number of seizures (1), plasma levels of anticonvulsant drugs (1), viral load (1), CD4 cell count (1), number of opportunistic infections (1), hospitalizations (1), percentages of sub-therapeutic international normalized ratio (INR) values (1), time within the therapeutic INR range (1) and 13C-urea breath test (1). The gene discussed is CD4; the disease is Opportunistic infection.