GPT and liver disorder: Among the 20 long-term responders to D-penicillamine, 6 (33%) continued therapy with this drug and obtained good control of hepatic disease (median ALT at the end of follow-up: 36 IU/L; range 12–77 IU/L), whereas 14 patients (69%) switched to zinc monotherapy (9 as maintenance therapy and 5 due to D-penicillamine-related adverse events).