PNPLA3 and metabolic dysfunction-associated steatotic liver disease: The question remains whether the polymorphisms in some of the significant drug targets and metabolism genes directly associated with NAFLD pathogenesis and drug metabolic genes can be correlated with a specific drug response, especially drugs that have shown promising therapeutic intervention such as Vitamin E. In addition, future research in the development and validation of non-invasive diagnostic tissue markers or biomarkers, for example, carrying of PNPLA3 risk allele for early intervention, might represent another area of scope to focus.