A study conducted on 34 CML patients that evaluated the effect of the ABCB1 c.3435C>T polymorphism on IM pharmacokinetics showed that individuals carrying the 3435CC genotype had a higher renal clearance of IM than individuals carrying the 3435CT and 3435TT genotypes (41). This evidence concerns the gene ABCB1 and chronic myelogenous leukemia, BCR-ABL1 positive.