INS and Hypoglycemia: However, since PUFA leads to a shift in voltage dependence of inactivation in the hyperpolarizing direction for voltage-gated Ca2+ and Na+ channels in cardiac myocytes (42, 43), a similar shift in the voltage dependence of calcium channel inactivation in pancreatic β-cells would be expected to reduce hypoglycemia by attenuating Ca2+ influx-dependent insulin secretion.