Another “indirect” transcriptional mechanism seems to be mediated by an interaction between CaMKII and calcineurin A. The phosphatase calcineurin A dephosphorylates nuclear factor of activated T-cells (NFAT), resulting in nuclear accumulation of NFAT and consequent activation of NFAT-dependent transcriptional programs and severe cardiac hypertrophy (Molkentin et al., 1998). Here, CAMK2G is linked to cardiac hypertrophy.