CAMK4 and cardiac hypertrophy: Whereas artificial overexpression of CaMKIV in a transgenic model was sufficient to induce cardiac hypertrophy in another study (Passier et al., 2000), in the model of Colomer, left ventricular CaMKIV was not detectable, and mice lacking CaMKIV did not display an altered response to TAC, indicating that CaMKIV is not required for cardiac hypertrophy.