CaMKII is known to phosphorylate HSF-1 at Ser-230 (Holmberg et al., 2001), and Wei Peng and colleagues provided data suggesting that this might be a CaMKII-dependent antiapoptotic mechanism during cardiac ischemia and reperfusion (Peng et al., 2010). The gene discussed is CAMK2G; the disease is myocardial ischemia.