A well-known transcription factor in striated muscle biology is SRF, and Calcium/Calmodulin-dependent regulation of SRF via interaction with CaMKIV and histone deacetylase 4 (HDAC4), but not CaMKII, was demonstrated to be involved in the development of cardiac hypertrophy (Davis et al., 2003). The gene discussed is HDAC4; the disease is cardiac hypertrophy.