In conclusion, the intravitreal dexamethasone implant treatment of patients with persistent diabetic macular edema in whom laser photocoagulation proved to be ineffective and who, as a result, required a monthly injection of anti-VEGF factors (Ranibizumab, Bevacizumab) may be a good alternative as it allows extending the interval between injections. This evidence concerns the gene VEGFA and diabetic macular edema.