IDH1 and acute myeloid leukemia: With recent progress in genomic technologies, a large number of recurrent somatic mutations have been discovered in AML, including mutations in ASXL1 [3], TET2 [4], IDH1/2 [5], DNMT3A [6, 7], PFH6 [8], and BCOR [9], thus providing new insights into the mechanisms of leukemogenesis and further evidence of the genetic complexity of AML.