DNMT3A and acute myeloid leukemia: The presence of unfavorable karyotype (P<0.001) and SNP-A lesion(s) (P = 0.001) independently predicted shorter OS in the whole cohort, while the presence of SNP-A lesion(s) (P = 0.006), DNMT3A mutations (P = 0.042) and randomization in the control arm (P = 0.043) independently predicted shorter OS in CN-AML patients (Table 4).