Interactions between the treatment effect on CR/CRp achievement, CIR and OS, respectively, and the following baseline patient characteristics were studied: cytogenetics, SNP-A karyotyping, FLT3–ITD, and NPM1 mutations in the whole cohort and in the CN-AML subset, additionally with DNMT3A mutations in the CN-AML subset. This evidence concerns the gene DNMT3A and acute myeloid leukemia.