Intriguingly, the enforced expression of miR-199b-5p profoundly reduced HES1 luciferase reporter activity in SKOV3 cells by 35% (Fig. 4E), indicating the JAG1-Notch1 signaling cascade could be suppressed by miR-199b-5p in ovarian cancer cells. The gene discussed is HES1; the disease is ovarian carcinoma.