NCOA1 and Familial prostate cancer: Indeed, Gregory et al., demonstrated that the coactivators SRC1 (Steroid Receptor Coactivator 1) and TIF2 (transcriptional intermediary factor 2) were over-expressed in the majority of CRPCs [29], and altered expression and localisation of AR corepressors in prostate cancer has also been described (for example [30-34]).