Our findings suggest that FRA1-regulated transcriptional events play an important role in this process, with elevated levels of pro-mesenchymal FRA1 targets associated with adverse outcomes in about half of all stage B and stage C cancers, while high levels of FRA1 gene (FOSL1) expression in these mesenchymal-type identifying cancers with poorest prognosis. Here, FOSL1 is linked to cancer.