TGFB1 and colorectal carcinoma: We found that an underlying function of FRA1 in CRC cells was to positively regulate TGFβ signaling, which it could do via several mechanisms; in the mesenchymal-like BE cell line, its binding modulated expression of multiple TGFβ pathway components, including maintaining operation of an autocrine TGFβ2 loop that promoted expression of mesenchymal genes.