However, the pattern of change with acclimatization in PaO2, PaCO2, SaO2, CaO2, P50, pH and [Hb] matches the pattern of change for AMS, cognitive function, and exercise performance, suggesting an underlying but complex relationship between oxygenation and other aspects of acclimatization. This evidence concerns the gene GSTM1 and ablepharon macrostomia syndrome.