Confocal microscopy of glioma cells revealed that similarly to PDGF-AA, HCMV induced stress fiber reorganization as demonstrated by vinculin and β3 integrin co-localization and this process was dependent on PDGFRα and Src activation, since it was blocked by pretreatment with 3G3 (10 μg/ml) or PP1 (2.5mM, Figure 1C). This evidence concerns the gene PDGFRA and central nervous system cancer.