This classification assigned the phosphoproteins to eight different signaling pathways: 1) VEGF signaling (1/13); 2) axon guidance mediated by semaphorins (3/13); 3) angiogenesis (1/13); 4) cytoskeletal regulation by Rho GTPase (2/13); 5) Alzheimer disease-presenilin (1/13); 6) Alzheimer disease-amyloid secretase (1/13); 7) pyrimidine metabolism (3/13); and 8) PDGF signaling (1/13) (Figure 1A). The gene discussed is VEGFA; the disease is early-onset autosomal dominant Alzheimer disease.