EPHA4 and amyotrophic lateral sclerosis: In addition, the EphA4 receptor has been described as involved in amyotrophic lateral sclerosis [68] and as a modulator of; ischemia-reperfusion [44], [70], contusive spinal cord injury [67], [69] and experimental autoimmune encephalomyelitis progression [70], supporting a role for EphA4 signalling in neuronal damage and neurodegeneration.