GATA6 and lung cancer: [34]. Increasing the downregulated noncanonical Wnt receptor Fzd2 with GATA 6 mutants was found to be able to partly reduce the lung epithelial defects induced by GATA6 mutants [35]. In addition to their physiological effects, the noncanonical Wnt pathway also participates in the carcinogenesis and invasion of lung cancer [36], [37].